Anti-tumor Drug Delivery and Tumor Therapy Based on Metal-organic Frameworks

VernacularTitle:基于金属有机框架材料的抗肿瘤药物递送与肿瘤治疗
Author: Bingtai LI ¹ ; Bangguo KOU ; Yongjie JIANG ; Pan BIAN ; Lanning YIN
Author Information

1. Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730000, China
Publication Type:Research Article
Keywords: Metal-organic frameworks; Drug delivery; Antitumor drug; Tumor therapy
From: Cancer Research on Prevention and Treatment 2022;49(8):832-837
CountryChina
Language:Chinese
Abstract: Metal-organic frameworks (MOFs) are mixed porous materials which are composed of metal clusters or ions and organic pillars. Given their channel tunability, high porosity, large specific surface area, and good biocompatibility, MOFs can be combined with various biological macromolecules. In recent years, they have been widely studied in the field of biomedicine, especially in the loading of anti-tumor drugs, showing great application prospects. Multifunctional anti-tumor MOF combined with different therapeutic methods provides a new idea and method for tumor treatment. On the basis of the structure of MOF, this paper introduces the advantages of using MOF to load anti-tumor drugs and reviews the application of MOF in tumor therapy.