Research Progress on Hyperthermia and Anti-Tumor Immunity
10.3971/j.issn.1000-8578.2022.22.0320
- VernacularTitle:肿瘤热疗与抗肿瘤免疫的研究进展
- Author:
Zhucheng YIN
1
;
Xinjun LIANG
Author Information
1. Department of Medical Oncology, Hubei Cancer Hospital, Wuhan 430079, China
- Publication Type:Research Article
- Keywords:
Hyperthermia;
Immunotherapy;
Anti-tumor Immunity;
Cytokine
- From:
Cancer Research on Prevention and Treatment
2022;49(8):827-831
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, with the development of comprehensive tumor therapy, hyperthermia has become one of the important means of cancer treatment. A large number of studies have shown that the removal of tumor cells depends on exogenous treatment methods and the body's own anti-tumor immune status. Hyperthermia cannot only directly kill tumor cells but also activate the body's immunity to exhibit an anti-tumor effect. In recent years, with the deepening of tumor research, hyperthermia has been able to create a type I tumor microenvironment with PD-L1 overexpression and enrichment of tumor-infiltrating lymphocytes, complementing the enhancement of immune checkpoint inhibitors. Hyperthermia combined with immunotherapy may offer a new perspective in cancer treatment. The mechanism of tumor hyperthermia and anti-tumor immunity and its clinical application have aroused great interest and become a new research field. This article reviews the relationship between tumor hyperthermia and anti-tumor immunity.
