Research Progress on Anti-Tumor Mechanism of Theaflavins Natural Products
10.3971/j.issn.1000-8578.2022.21.1292
- VernacularTitle:茶黄素类天然产物抗肿瘤机制的研究进展
- Author:
Xue ZHANG
1
;
Junli YIN
;
Jiaxiang WANG
;
Wengui SHI
;
Zuoyi JIAO
Author Information
1. Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou 730030, China
- Publication Type:Research Article
- Keywords:
Theaflavins;
Signal path;
Anticancer;
Mechanism
- From:
Cancer Research on Prevention and Treatment
2022;49(8):820-826
- CountryChina
- Language:Chinese
-
Abstract:
Theaflavins are a class of natural products extracted from black tea or green tea, with significant anti-tumor effects on gastric cancer, liver cancer, breast cancer and other tumors. Theaflavins were once considered as the new products for anticancer therapy. However, the anti-tumor mechanism of theaflavins involves a variety of biological processes, and the regulation is complex. Therefore, this article summarizes the role of theaflavins in promoting tumor cell apoptosis, inducing tumor cell mitotic arrest and regulating tumor immunity, and reviews the inhibition of tumorigenesis and growth through MAPK, PI3K/AKT, Hedgehog, NF-κB, JAK/STAT and Wnt/β-Catenin signal pathways, in order to provide new ideas for cancer treatment and anti-cancer drug development.
