Research Progress of Lipid Metabolism Reprogramming in Prostate Cancer

VernacularTitle:脂代谢重编程在前列腺癌中的研究进展
Author: Kai ZENG ¹ ; Jihong LIU ; Qiang LI ; Qinzhang WANG
Author Information

1. Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Publication Type:Research Article
Keywords: Prostate cancer; Metabolic reprogramming; Lipid metabolism; Fatty acid oxidation
From: Cancer Research on Prevention and Treatment 2022;49(8):774-779
CountryChina
Language:Chinese
Abstract: Metabolism reprogramming plays an important role in the process of tumor occurrence and development, and provides the necessary material basis for tumor cells. It can change the metabolic patterns of amino acids, glucose and fatty acids in tumor cells, which is one of the hallmark features of tumors. At present, it is shown that most tumors tend to take advantage of glycolysis for energy resource. In contrast, studies have shown that prostate cancer cells dependent more on the fatty acid oxidation pathway for metabolic reprogramming to obtain energy substances. Therefore, it is of great significance to understand the relation between key enzymes of lipid metabolism and regulatory genes for early diagnosis, targeted treatment and better prognosis of prostate cancer.