Research Progress of Genes Related to Treatment and Prognosis of Alpha-fetoprotein Producing Gastric Cancer

VernacularTitle:产甲胎蛋白胃癌治疗及预后相关基因的研究进展
Author: Shunli LU ¹ ; Jianping YU ; Weikai CHEN ; Andong LI ; Qingyuan HE ; Chao CHEN ; Xiaopeng HAN
Author Information

1. The First Clinical Medicine College of Gansu University of Chinese Medicine, Lanzhou 730000, China
Publication Type:Research Article
Keywords: Alpha-fetoprotein producing gastric cancer; Genes; Molecular Mechanisms; Therapy; Prognoses
From: Cancer Research on Prevention and Treatment 2022;49(7):738-744
CountryChina
Language:Chinese
Abstract: Alpha-fetoprotein producing gastric cancer (AFPGC) is a special type of gastric cancer. AFPGC is considered to be the most highly invasive tumor with a high degree of malignancy and prone to metastasis. As a consequence, it usually causes unsatisfied treatment effect and the prognosis is poor. At present, treatment methods and monitoring indicators have limited effect on AFPGC. VEGF, HER2, AFP, GPC3 and SALL4 are cogently associated with tumor genesis and development. If we can reasonably guide the treatment and prognosis of AFPGC patients, it will greatly improve the situation of patients and improve the survival of patients. This article reviews the research progress of the genes related to the treatment and prognosis of AFPGC.