Research Progress of M2-type Tumor-associated Macrophages in Lung Cancer

VernacularTitle:M2型肿瘤相关巨噬细胞在肺癌中的研究进展
Author: Xiaoying WAN ¹ ; Songwen ZHOU
Author Information

1. Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China
Publication Type:Research Article
Keywords: Lung cancer; Tumor-associated macrophages; Tumor microenvironment
From: Cancer Research on Prevention and Treatment 2022;49(7):733-737
CountryChina
Language:Chinese
Abstract: Tumor-associated macrophages (TAMs) account for a large proportion in tumor stroma, and can be divided into M1 type (anti-tumoral) and M2 type (pro-tumoral). Recently, many experimental and clinical studies have shown that M2-type TAMs are significantly correlated with tumor stage, tumor cell differentiation, depth of invasion, angiogenesis, lymph node metastasis and therapeutic drug resistance, which eventually affects the prognosis of tumor patients. Targeted TAMs therapy is expected to benefit cancer patients. This paper reviews the recent research of M2-type TAMs in lung cancer.