Efficacy and Adverse Reaction of Tislelizumab Combined with Chemotherapy on Urothelial Carcinoma
10.3971/j.issn.1000-8578.2022.21.1340
- VernacularTitle:替雷利珠单抗联合化疗在尿路上皮癌中的疗效及不良反应分析
- Author:
Zongjie WEI
1
;
Youlin KUANG
;
Yong CHEN
;
Lu WANG
;
Xiao CHEN
;
Xin GOU
Author Information
1. Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- Publication Type:Research Article
- Keywords:
Tislelizumab;
Chemotherapy;
Urothelial cancer;
Efficacy;
Adverse reaction
- From:
Cancer Research on Prevention and Treatment
2022;49(7):698-702
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of tislelizumab combined with chemotherapy in the treatment of urothelial carcinoma in the real word. Methods We enrolled 32 patients with urothelial carcinoma who were treated with tislelizumab and chemotherapy (gemcitabine/cisplatin or paclitaxel). The incidence of treatment-related adverse reactions during treatment and the efficacy evaluation were statistically analyzed. Results All patients were divided into two groups: 15 patients in the tislelizumab combined with paclitaxel group and 17 patients in the tislelizumab combined with GC group. Among 24 efficacy-evaluable patients, the ORR was 54.2% and the DCR was 83.3%. The ORR were 50.0% and 58.3%, and the DCR were 75.0% and 91.7% in the tislelizumab combined with paclitaxel group and the tislelizumab combined with GC group respectively. Common treatment-related adverse reactions included anemia (56.3%), loss of appetite (53.1%) and skin pruritus (50.0%). The grade 3-4 treatment-related adverse events occurred in 21.8% of patients. Common immune-related adverse reactions included skin toxicity (53.1%) and immune colitis (9.4%). Conclusion Tislelizumab combined with chemotherapy on urothelial cancer has significant curative effect, safety and controllability, but attention should be paid to immune-related adverse reactions.
