Diagnostic Value of Serum LncRNAs for Bone Metastasis in Lung Cancer
10.3971/j.issn.1000-8578.2022.21.1047
- VernacularTitle:血清LncRNAs对肺癌骨转移的诊断价值
- Author:
Peng ZHANG
1
;
Min GAO
;
Feifei FENG
;
Mengyuan LI
;
Jinyan LIU
;
Lingling HUANG
Author Information
1. Department of Bone and Soft Tissue Sarcoma, The Affiliated Cancer Hospital of Zhengzhou University (Henan Cancer Hospital), Zhengzhou 450008, China
- Publication Type:Research Article
- Keywords:
LncRNA;
Biomarkers;
Lung cancer with bone metastasis;
Lung cancer
- From:
Cancer Research on Prevention and Treatment
2022;49(6):593-598
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of lncRNA HOTAIR, HOTAIR, CRNDE and AFAP1-AS1 in lung cancer patients with bone metastasis (LCWBM), and to elucidate the diagnostic value of lncRNAs for LCWBM. Methods Serum was collected from 38 LCWBM patients and 38 lung cancer without bone metastasis (LCWOBM) patients. Questionnaires were used to collect basic information of patients. Fasting peripheral venous blood of patients was collected to separate serum. qRT-PCR was used to measure the expression levels of four serum lncRNAs, and their diagnostic value for LCWBM was analyzed. Results The expression of serum HOTAIR was decreased in LCWBM patients, compared with LCWOBM patients (P < 0.05); the AUC of serum HOTAIR diagnosing LCWBM was 0.722 (sensitivity was 70.0%, specificity was 81.3%). And the level of serum HOTTIP was significantly increased in LCWBM patients, compared with LCWOBM patients (P < 0.05); AUC of serum HOTTIP diagnosing LCWBM was 0.784 (sensitivity was 100.0%, specificity was 45.5%). The AUC of serum HOTAIR combined with HOTTIP diagnosing LCWBM was 0.818 (sensitivity, specificity, positive predictive value and negative predictive value were 87.5%, 72.7%, 70.0% and 88.9%, respectively). Conclusion Serum lncRNA HOTAIR and HOTTIP might be potential diagnostic biomarkers for bone metastases in lung cancer patients.
