Correlation of Metabolic Syndrome and Low-level High-density Lipoprotein Cholesterol with Adverse Pathological Features of Prostate Cancer After Radical Prostatectomy
10.3971/j.issn.1000-8578.2022.21.1112
- VernacularTitle:代谢综合征及低水平高密度脂蛋白胆固醇与前列腺癌根治术后不良病理特征的相关性
- Author:
Junling HAN
1
;
Kun CHEN
;
Xiaolei ZHAI
;
Qianhe HAN
;
Zhongjie SHAN
Author Information
1. Department of Urology, People's Hospital of Zhengzhou, Zhengzhou 450003, China
- Publication Type:Research Article
- Keywords:
Metabolic syndrome;
HDL-C;
Prostate cancer;
Radical prostatectomy
- From:
Cancer Research on Prevention and Treatment
2022;49(5):459-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the association of metabolic syndrome (MetS) and low-level high density lipoprotein-cholesterol (HDL-C) with the invasion of prostate cancer (PCa) in the patients after radical prostatectomy (RP). Methods We collected and analyzed the data of 232 PCa patients treated with RP for prospective multicenter clinical study.The MetS was assessed according to NCEP-ATP Ⅲ.Patients were divided into MetS group and non-MetS group.Locally advanced PCa was defined as a pT-stage≥3.ISUP Gleason grading system (GS) were used for pathological grading.Logistic regression analyses assessed the association of MetS and its components with pathological data. Results MetS was an independent risk factor for GS≥8 after RP.Low HDL-C level was associated with locally advanced PCa.The risks of adverse pathological features increased with the number of MetS components. Conclusion Low HDL-C level and 4 or more MetS components are associated with higher risk of adverse pathological features of PCa.
