Epidemiological and Clinical Characteristics of Fibrous Dysplasia of Bone
10.3971/j.issn.1000-8578.2022.22.0231
- VernacularTitle:骨纤维结构不良的流行病学与临床分析
- Author:
Hairong XU
1
;
Yuan LI
;
Huachao SHAN
;
Feng YU
;
Xiaohui NIU
Author Information
1. Department of Orthopedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Beijing 100035, China
- Publication Type:Research Article
- Keywords:
Fibrous dysplasia of bone;
Epidemiology;
Pathological fracture;
Malignant transformation
- From:
Cancer Research on Prevention and Treatment
2022;49(5):408-411
- CountryChina
- Language:Chinese
-
Abstract:
Objective To describe the epidemiological and clinical characteristics of fibrous dysplasia of bone admitted to a single center in the past 30 years. Methods We analyzed the clinical features of 744 patients with bone fibrous dysplasia diagnosed by pathology, including age, gender, disease location, monostotic or polyostotic lesions, pathological fracture and malignant transformation. Results There were 1183 lesions in 744 patients. The mean age at admission was 31.1±13.5 years old. The ratio of male to female was close to 1:1. The most common site was the lower extremities (916(77.4%)), followed by the upper extremities (106(9.0%)). The most common sites of lower extremities were the femur (645(54.5%)) and the tibia (224(18.9%)). Polyostotic cases accounted for 25.4%, and monostotic cases accounted for 74.6%. Pathological fracture occurred in 163 (13.8%) patients. There were 6 (0.8%) patients with malignant transformation. The mean age was 40.5 years old. The mean time of malignant transformation was 7.7 years. Conclusion Fibrous dysplasia of bone is a rare group of benign bone tumors, with typical epidemiological and clinical features.
