Research Progress of Immune Microenvironment in Multiple Myeloma
10.3971/j.issn.1000-8578.2022.21.1427
- VernacularTitle:多发性骨髓瘤免疫微环境的研究进展
- Author:
Jian HOU
1
;
Junying WANG
Author Information
1. Department of Hematology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
- Publication Type:Research Article
- Keywords:
Multiple myeloma;
Immune microenvironment;
Immunotherapy;
T lymphocyte;
Natural killer cells
- From:
Cancer Research on Prevention and Treatment
2022;49(5):375-378
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma is one type of hematological malignancy, characterized by the proliferation and accumulation of monoclonal plasma cells in bone marrow. Bone marrow microenvironment plays a key supporting role in the proliferation and survival of myeloma cells, where a large number of immune cells exist but are functionally suppressed. Based on the studies of myeloma immune microenvironment in recent years, we summarize the recent advances and existing problems in the treatment of multiple myeloma and put forward some considerations and suggestions, to provide references for researchers in this field.
