Role and Mechanism of BDH2 Gene in Metabolism, Tumorigenesis and Progression of Cancer
10.3971/j.issn.1000-8578.2022.21.0995
- VernacularTitle:BDH2基因在代谢与肿瘤发生发展中的作用与机制
- Author:
Bingchun LIU
1
;
Kang LI
;
Jianlong YUAN
Author Information
1. Stem Cell Research Center, Engineering Laboratory for Genetic Test and Research of Tumor Cells, The Affiliated Hospital of Inner Mongolia Medical University, Huhhot 010050, China
- Publication Type:Research Article
- Keywords:
BDH2;
Iron metabolism;
Tumorigenesis
- From:
Cancer Research on Prevention and Treatment
2022;49(3):230-234
- CountryChina
- Language:Chinese
-
Abstract:
Cellular metabolism in tumor is an important biological process to promote the occurrence and development of tumor, and the genes related to cellular metabolism are gradually becoming the targets of tumor treatment. However, more researches are still needed to explore the abnormal metabolism in tumor progression and its prognostic value. BDH2 gene is a multifunctional gene, participates in a variety of metabolic pathways, plays an important catalytic role in iron metabolism, participates in ketone metabolism and is related to lipid metabolism. In recent years, researchers have found that BDH2 plays distinct roles in various types of tumors. The occurrence and development of a variety of tumors are closely related to BDH2. This paper analyzes, summarizes and prospects the role and mechanism of BDH2 in metabolism and tumorigenesis.
