Dormancy and Survival Mechanism of Disseminated Tumor Cell and Its Role in Prevention and Treatment of Solid Tumor Metastasis
10.3971/j.issn.1000-8578.2022.21.0968
- VernacularTitle:播散肿瘤细胞的休眠与存活机制及其在防治实体瘤转移中的作用
- Author:
Zujun QUE
1
;
Zhichao XI
;
Hongxi XU
;
Jianhui TIAN
Author Information
1. Clinical Oncology Center, Shanghai Municipal Hospital of TCM, Shanghai University of TCM, Shanghai 200071, China
- Publication Type:Research Article
- Keywords:
Cancer;
Disseminated tumor cells;
Metastasis;
Tumor dormancy;
Solid tumor
- From:
Cancer Research on Prevention and Treatment
2022;49(2):154-158
- CountryChina
- Language:Chinese
-
Abstract:
The prevention and treatment of tumor metastasis can significantly improve the survival of patients with solid tumors. However, there is still a lack of effective drugs for the prevention and treatment of metastasis. The main reason is that the existing intervention and therapeutic drugs are difficult to achieve precise prevention and treatment of metastasis. Due to disseminated tumor cells (DTCs) already exist in the metastatic target organs of early postoperative patients, they are difficult to be detected with existing imaging techniques, and there is a lack of effective intervention drugs and efficacy evaluation systems. When DTCs grow to be detectable by imaging, the patient is already in the advanced stage of cancer, which has become a bottleneck restricting the breakthroughs in metastasis prevention and treatment. This paper reviews the dormancy and survival mechanism of DTCs in metastatic target organs and its intervention strategies, in order to promote the curative effect of metastasis prevention and treatment.
