Recent Advances in Tumor Therapy Targeting FGFR
10.3971/j.issn.1000-8578.2022.21.0768
- VernacularTitle:靶向FGFR的肿瘤治疗新进展
- Author:
Jing ZHANG
1
;
Chen WANG
;
Baohong GU
;
Yaqing ZHANG
;
Hao CHEN
Author Information
1. Department of Clinical Medicine, Lanzhou University Second Hospital, Lanzhou 730000, China
- Publication Type:Research Article
- Keywords:
Cancer;
FGFR;
FGF;
Targeted therapy;
FGFR inhibitors;
Signal pathway
- From:
Cancer Research on Prevention and Treatment
2022;49(2):148-153
- CountryChina
- Language:Chinese
-
Abstract:
Abnormal FGFR signaling has been found in a variety of cancers. The abnormal FGFR signaling is involved in several processes of tumorigenesis which include cell survival, proliferation, inflammation, migration, angiogenesis, epithelial-mesenchymal transformation and drug resistance. Therefore, FGFR is a very promising target for the treatment of tumors. More and more FGFR inhibitors have been developed for preclinical and clinical trials, and some FGFR inhibitors have been used in clinical applications. However, the problems such as acquired resistance and systemic toxicity have hindered the application of FGFR inhibitors. This paper reviews the clinical application of common FGFR inhibitors and summarizes the problems and solutions in their application.
