Influence of LMR and LMR/LDH on Prognosis of Primary Waldeyer's Ring Diffuse Large B-cell Lymphoma
10.3971/j.issn.1000-8578.2022.21.0521
- VernacularTitle:LMR和LMR/LDH对原发韦氏环弥漫大B细胞淋巴瘤预后的影响
- Author:
Qi LIU
1
;
Peng GUO
;
Wenhua ZHAN
Author Information
1. Graduate Institute of Ningxia Medical University, Yinchuan 750004, China
- Publication Type:Research Article
- Keywords:
Diffuse large B-cell lymphoma;
Waldeyer's Ring;
Lymphocyte/monocytes;
Lactate dehydrogenase;
Prognosis
- From:
Cancer Research on Prevention and Treatment
2022;49(2):110-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of peripheral blood LMR and LMR/LDH on the prognosis of primary Waldeyer's Ring DLBCL patients. Methods We collected 71 patients with primary Waldeyer's Ring DLBCL. The ROC curve was used to determine the optimal critical values of LMR and LMR/LDH before treatment. The chi-square test was used to analyze the constituent ratio and rate of high and low LMR groups as well as high and low LMR/LDH groups. Kaplan-Meier method was used to calculate survival rate. Log rank method and Cox risk regression model were used for univariate and multivariate analyses, respectively. Results The optimal critical values of LMR and LMR/LDH were 2.97 and 1.56, respectively. The prognosis of patients in the high LMR group was significantly better than that in the low LMR group (P < 0.001). The prognosis of patients in the high LMR/LDH group was significantly better than that in the low LMR/LDH group (P < 0.001). Univariate analysis showed that age, B symptoms, clinical stage, treatment efficacy, IPI score, LDH level, LMR and LMR/LDH were important factors that influenced the prognosis of early-stage Waldeyer's Ring DLBCL. Multivariate analysis showed that the age, clinical stage and LMR/LDH were independent prognostic factors. Conclusion LMR and LMR/LDH before treatment may have certain value in predicting the prognosis of Waldeyer's Ring DLBCL patients.
