Expression and Prognostic Value of Inward Rectifier Potassium Channel Subfamily J Member 11 mRNA in Gliomas
10.3971/j.issn.1000-8578.2022.21.0574
- VernacularTitle:内向整流型钾离子通道亚家族J成员11 mRNA在脑胶质瘤中的表达及预测预后价值
- Author:
Fang WANG
1
;
Kaijia ZHOU
;
Zheng ZHAO
;
Hui LIANG
;
Yanwei LIU
Author Information
1. Department of Encephalopathy, People's Hospital of Fujian University of Traditional Chinese Medicine, Fujian Provincial People's Hospital, Fuzhou 350014, China
- Publication Type:Research Article
- Keywords:
Glioma;
KCNJ11;
Molecular typing;
Mechanism
- From:
Cancer Research on Prevention and Treatment
2022;49(1):18-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of KCNJ11 mRNA in gliomas and its prognostic value. Methods The clinical, histopathological and molecular pathological features of 273 patients with gliomas were collected from CGGA. We analyzed the differences of KCNJ11 mRNA expression in different types of gliomas and the survival time of patients with high and low expression of KCNJ11 mRNA in different subtypes of gliomas. Results The expression levels of KCNJ11 mRNA in young glioma and primary glioma patients were higher than those in old glioma and recurrent glioma patients, respectively (P=0.008, 0.001). The expression of KCNJ11 mRNA in oligodendroglioma was the highest, astrocytoma was the second, and glioblastoma was the lowest (P=0.000). The expression of KCNJ11 mRNA in WHOⅡ grade glioma was the highest, WHOⅢ was the second, and WHOⅣ was the lowest (P=0.000). The expression levels of KCNJ11 mRNA in IDH-mutant type glioma patients were higher than those in IDH-wild type glioma patients (P=0.000). The expression of KCNJ11 mRNA in deletion of 1p/19q glioma patients was higher than that in non-deletion of 1p/19q ones (P=0.000). The expression of KCNJ11 mRNA in MGMT methylated glioma patients was higher than that in non-methylated ones (P=0.036). The survival time of patients with high expression of KCNJ11 mRNA (≥2.77) was longer than that with low expression (P=0.000). Multivariate Cox analysis showed that the high expression of KCNJ11 mRNA was an independent factor affecting the good prognosis of patients with glioma. Conclusion The expression of KCNJ11 mRNA is negatively related to the malignant degree of the tumor. The high expression of KCNJ11 mRNA is an independent factor affecting the good prognosis of patients with glioma.
