Effect of Systemic Administration of Granulocyte-Colony Stimulating Factor on Rate of Fracture Healing of Bone Defect in Goats as Animal Model
https://doi.org/10.47836//mjmhs18.4.28
- Author:
Collin S. K. Looi
1
;
Nurul H. Khairuddin
2
;
Hui Cheng Chen
2
;
Rajesh Ramasamy
1
;
Seng Fong Lau
2
;
Sharifah A. Roohi
3
Author Information
1. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
2. Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
3. Hand and Upper Limb Centre, Pantai Hospital Kuala Lumpur, 8, Jalan Bukit Pantai, Bangsar, Kuala Lumpur, Malaysia
- Publication Type:Other Types
- Keywords:
Granulocyte-Colony Stimulating Factor, Goat animal model, Non-union fracture, Bridging and union, Tibial bone defect
- From:Malaysian Journal of Medicine and Health Sciences
2022;18(No.4):211-217
- CountryMalaysia
- Language:English
-
Abstract:
Granulocyte-colony stimulating factor (G-CSF) serves as an important cytokine in haematopoiesis; released at both
physiological and pathological conditions by a range of cells. We hypothesized that the systemic administration of
G-CSF would produce an accelerated fracture-healing rate in non-union bone defects; thus, potentially leading to
useful clinical applications. Ten male adult Katjang goats, weighing about 15-26 kilograms were randomly chosen
and a tibial bone defect was induced in each animal. The defect was maintained by internal fixation with a titanium
plate and reinforced by an external fiberglass cast. Post-operative radiographs were performed twice weekly and
radiographic assessments were performed by evaluating the bridging and union measurements through a validated
method. In the treatment group, the time for bridging and union exhibited statistically significant differences when
compared with a control group. The outcomes of the present study establishing a notion that administration of G-CSF
besides inducing haematopoiesis, promotes healing of fractures and non-union bone defects as well.
- Full text:11.2022my1316.pdf
