Effect of Lactate on Immune Cells in Tumor Microenvironment and Progress of Related Target Therapy
10.3971/j.issn.1000-8578.2023.22.1076
- VernacularTitle:乳酸对肿瘤微环境内免疫细胞的影响及相关靶点治疗的研究进展
- Author:
Mengru JIN
1
;
Li WANG
;
Yanjing LI
Author Information
1. Department of Gastroenterology, Harbin Medical University Cancer Hospital, Harbin 150081, China
- Publication Type:Research Article
- Keywords:
Lactate;
Immune cell;
Tumor microenvironment;
Tumor;
Aerobic glycolysis;
Immune escape
- From:
Cancer Research on Prevention and Treatment
2023;50(6):634-640
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between tumor metabolism and immunity is complex and diverse. To date, the role of tumor-specific metabolic reprogramming in shaping the specific tumor microenvironment in tumor immunotherapy remains unclear. Lactic acid is the main product of glycolysis, and the aerobic glycolysis of tumor cells causes lactic acid to accumulate in the microenvironment. Recent studies have shown that the accumulation of lactic acid in the tumor microenvironment hinders anti-tumor immunity, especially affects the function, differentiation, and metabolism of immune cells, and participates in tumor immune escape, thus promoting tumor. This article reviews the effects of lactate accumulation in the tumor microenvironment on dendritic cells, T cells, NK cells, tumor-associated macrophages, and myeloid-derived suppressor cells. Targeted intervention of lactate production and efflux by tumor cells is expected to become a new strategy for tumor immunotherapy.
