Research Progress of Key Molecular Events Related to Progression of Colorectal Cancer
10.3971/j.issn.1000-8578.2023.22.1242
- VernacularTitle:结直肠癌进展相关关键分子事件研究进展
- Author:
Xiong ZHOU
1
;
Ming HU
;
Dongming JIANG
;
Guangwen CAO
;
Xiaojie TAN
Author Information
1. Department of Epidemiology, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China
- Publication Type:Research Article
- Keywords:
Colorectal cancer;
Malignant progression;
Genetic variation;
Molecular events
- From:
Cancer Research on Prevention and Treatment
2023;50(6):609-615
- CountryChina
- Language:Chinese
-
Abstract:
The continuous development of high-throughput and single-cell sequencing technologies and the emergence of spatial transcriptome sequencing have allowed the continuous discovery of temporal and spatial molecular events in the progression of colorectal cancer (CRC) to better understand its mechanism of malignant progression. Genetic variations (mutation of APC and P53, etc.) and mismatch repair of DNA, posttranscriptional regulation, such as epigenetic alteration, and dynamic alteration of complex molecular networks have their own special molecules that play key roles. Drug resistance and metastasis in the late stage of CRC progression are closely related to these key molecular events. This article reviews the research progress and explores key molecular events in the malignant progression of CRC to provide scientific basis and ideas for elucidating the regulatory mechanism of CRC and evaluating its prognosis prediction and treatment.
