Progress of Different Programmed Cell Death Pathways in Kidney Cancer
10.3971/j.issn.1000-8578.2023.22.1100
- VernacularTitle:不同类型程序性细胞死亡途径在肾癌中的研究进展
- Author:
Mingzhe WU
1
;
Fuchun WANG
;
Haojie PAN
;
An'an ZHOU
;
Xi XIAO
;
Junqiang TIAN
Author Information
1. Department of Urology, The Second Hospital of Lanzhou University, Lanzhou 730000, China
- Publication Type:Research Article
- Keywords:
Kidney cancer;
Programmed cell death;
Apoptosis;
Autophagy;
Necroptosis;
Pyroptosis;
Ferroptosis
- From:
Cancer Research on Prevention and Treatment
2023;50(5):531-537
- CountryChina
- Language:Chinese
-
Abstract:
Programmed cell death (PCD) is a genetically determined, active and orderly cell death in the organism, and it affects the evolution of the organism, maintenance of its homeostasis, and development of several tissues and organs. The abnormal regulation of this process is closely related to various human diseases, including cancer. The identified pathways of PCD include apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis, which can be activated when cells are stimulated by various internal and external environmental factors. These pathways can induce cell death or maintain cell survival in kidney cancer cells under the regulation of various signaling molecules, thus affecting tumor progression or therapeutic efficacy. In this paper, the role of these PCD pathways in the development of kidney cancer was reviewed in light of recent research advances to provide new directions for the in-depth study of the pathogenesis of kidney cancer and the development of targeted antitumor drugs.
