Analysis of Tumor Immune Microenvironment Based on Bulk RNA-sequencing Data and Its Application
10.3971/j.issn.1000-8578.2023.22.1027
- VernacularTitle:基于批量转录组测序分析肿瘤免疫微环境及其应用
- Author:
Xiao CHEN
1
;
Quan LIU
;
Huan REN
Author Information
1. School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China
- Publication Type:Research Article
- Keywords:
Tumor;
Immune microenvironment;
Immunotherapy;
Bulk transcriptome sequencing;
Deconvolution;
Algorithmic tools
- From:
Cancer Research on Prevention and Treatment
2023;50(5):458-462
- CountryChina
- Language:Chinese
-
Abstract:
Cancer immunotherapy is one of the most promising biological therapies. The dynamic changes of the immune microenvironment of heterogeneous tumors are critical factors in determining the interaction and therapeutic efficacy between tumor and immune microenvironment. Therefore, quantitative analysis of its constituent cells, related genes, and phenotypes in real time is of great importance. The methods used to analyze tumor immune microenvironment include immunohistochemistry, flow cytometry and so on. With the development of next-generation sequencing technology, transcriptome RNA sequencing data analysis has become one of the important methods to determine the composition of tumor immune microenvironment. This article focuses on the common methods of bulk RNA sequencing data analysis and related research progress.
