Macrophage heterogeneity role in NAFLD and NASH disease progression.
10.3760/cma.j.cn501113-20220428-00223
- Author:
Tao YANG
1
;
Xiao WANG
2
;
Long Feng JIANG
2
;
Jun LI
2
Author Information
1. Department of Infectious Disease, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China The Affiliated People's Hospital with Jiangsu University, Zhenjiang 212001,China.
2. Department of Infectious Disease, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
- Publication Type:Journal Article
- Keywords:
Hepatic macrophage;
Non-alcoholic fatty liver disease;
Non-alcoholic steatohepatitis
- MeSH:
Humans;
Non-alcoholic Fatty Liver Disease/pathology*;
Liver/pathology*;
Macrophages/metabolism*;
Liver Cirrhosis/complications*;
Disease Progression
- From:
Chinese Journal of Hepatology
2023;31(7):770-775
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is a type of metabolic stress liver injury that is closely associated with insulin resistance and genetic susceptibility. The continuum of liver injury in NAFLD can range from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) and even lead to cirrhosis and liver cancer. The pathogenesis of NAFLD is complicated. Pro-inflammatory cytokines, lipotoxicity, and gut bacterial metabolites play a key role in activating liver-resident macrophages (Kupffer cells, KCs) and recruiting circulating monocyte-derived macrophages (MoDMacs) to deposit fat in the liver. With the application of single-cell RNA-sequencing, significant heterogeneity in hepatic macrophages has been revealed, suggesting that KCs and MoDMacs located in the liver exert distinct functions in regulating liver inflammation and NASH progression. This study focuses on the role of macrophage heterogeneity in the development and occurrence of NAFLD and NASH, in view of the fact that innate immunity plays a key role in the development of NAFLD.
