Histopathological evaluation of cirrhosis reversal.
10.3760/cma.j.cn501113-20230421-00185
- Author:
Wen ZHANG
1
;
Ya Meng SUN
1
;
Shu Yan CHEN
1
;
Hong YOU
1
Author Information
1. Liver Research Center, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
Liver biopsy;
Liver cirrhosis;
Pathology;
Reversal
- MeSH:
Humans;
Liver Cirrhosis/pathology*;
Liver/pathology*;
Hypertension, Portal;
Hepatocytes/pathology*;
Prognosis
- From:
Chinese Journal of Hepatology
2023;31(7):677-680
- CountryChina
- Language:Chinese
-
Abstract:
A normal liver can develop cirrhosis through long-term and repeated stimulation from various etiologies. Histological manifestations like the collapse of hepatic lobular structure (including microvascular structure) and the formation of pseudolobules can lead to portal hypertension and even decompensated cirrhosis. More and more evidence suggests that effective etiological treatment can not only delay but also reverse the progression of cirrhosis. The mechanism of cirrhosis reversal mainly includes the degradation of extracellular matrix, hepatocyte regeneration, and hepatic lobular remodeling. The "gold standard" for the evaluation of cirrhosis reversal at present is still a liver biopsy. Therefore, the histopathological evaluation of cirrhosis reversal is very important for determining the disease's prognosis, efficacy, and mechanism of exploration.
