Overview and prospects of an in vitro cell model for studying liver fibrosis.
10.3760/cma.j.cn501113-20220324-00138
- Author:
Qing Juan WU
1
;
Wen Liang LYU
1
Author Information
1. Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China.
- Publication Type:Journal Article
- Keywords:
Cell model;
Hepatic stellate cells;
Liver cirrhosis;
Liver sinusoidal endothelial cells;
Vitro model
- MeSH:
Humans;
Liver Cirrhosis/pathology*;
Hepatic Stellate Cells;
Cell Culture Techniques;
Endothelial Cells
- From:
Chinese Journal of Hepatology
2023;31(6):668-672
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis incidence and adverse outcomes are high; however, there are no known chemical drugs or biological agents that are specific and effective for treatment. The paucity of a robust and realistic in vitro model for liver fibrosis is one of the major causes hindering anti-liver fibrosis drug development. This article summarizes the latest progress in the development of in vitro cell models for liver fibrosis, with a focus based on the analysis of induction and activation of hepatic stellate cells, cell co-culture, and 3D model co-construction, as well as concurrent potential methods based on hepatic sinusoidal endothelial cell establishment.
