Statin-related drug-induced liver injury.
10.3760/cma.j.cn501113-20230418-00174
- Author:
Xiao Yun LI
1
;
Wei ZHONG
1
;
Yi Min MAO
1
Author Information
1. Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai Research Center of Fatty Liver Disease, Shanghai 200001, China.
- Publication Type:Journal Article
- Keywords:
Atorvastatin;
Drug-induced liver injury;
Hepatotoxicity;
Statins
- MeSH:
Humans;
Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects*;
Atorvastatin/adverse effects*;
Simvastatin/adverse effects*;
Chemical and Drug Induced Liver Injury/drug therapy*;
Drug-Related Side Effects and Adverse Reactions/drug therapy*
- From:
Chinese Journal of Hepatology
2023;31(6):659-663
- CountryChina
- Language:Chinese
-
Abstract:
Statins are a kind of prescription drug that is widely used to treat hyperlipidemia, coronary artery disease, and other atherosclerotic diseases. A common side effect of statin use is a mild rise in liver aminotransferases, which occurs in less than 3% of patients. Statin-related liver injury is most commonly caused by atorvastatin and simvastatin, but severe liver injury is uncommon. Therefore, understanding and evaluating hepatotoxicity and weighing the benefits and risks is of great significance to better realize the protective effect of statins.
