Regulation and influence of mitochondria on macrophages during hepatitis B virus infection.
10.3760/cma.j.cn501113-20220324-00139
- VernacularTitle:乙型肝炎病毒感染过程中线粒体对巨噬细胞的调控和影响
- Author:
Meng HONG
1
;
Qiu Xian ZHENG
1
;
Zhi CHEN
1
Author Information
1. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Macrophage;
Mitochondria
- MeSH:
Humans;
Hepatitis B virus/physiology*;
Hepatitis B/complications*;
Hepatitis B, Chronic/complications*;
Mitochondria;
Liver Neoplasms;
Macrophages
- From:
Chinese Journal of Hepatology
2023;31(6):649-652
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) infection is an important public health concern, as approximately 3.5% of the world's population is currently chronically infected. Chronic HBV infection is the primary cause of cirrhosis, hepatocellular carcinoma, and deaths related to liver disease globally. Studies have found that in HBV infection, viruses can directly or indirectly regulate mitochondrial energy metabolism, oxidative stress, respiratory chain metabolites, and autophagy, thereby altering macrophage activation status, differentiation types, and related cytokine secretion type and quantity regulations. Therefore, mitochondria have become an important signal source for macrophages to participate in the body's immune system during HBV infection, providing a basis for mitochondria to be considered as a potential therapeutic target for chronic hepatitis B.
