Assessment of liver transplant benefit and a novel strategy for liver donor allocation in acute-on-chronic liver failure.
10.3760/cma.j.cn501113-20230502-00202
- VernacularTitle:慢加急性肝衰竭肝移植的获益评估及供肝分配新策略
- Author:
Peng LI
1
;
Jun LI
1
Author Information
1. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
- Publication Type:Journal Article
- Keywords:
Acute-on-chronic liver failure;
Liver transplantation;
Prediction;
Prognosis;
Survival benefit
- MeSH:
Humans;
Liver Transplantation;
Acute-On-Chronic Liver Failure;
Prognosis;
Liver Cirrhosis
- From:
Chinese Journal of Hepatology
2023;31(6):569-573
- CountryChina
- Language:Chinese
-
Abstract:
Acute-on-chronic liver failure (ACLF) is a type of complex clinical syndrome that is mainly characterized by acute deterioration of liver function based on chronic liver disease, hepatic and extrahepatic organ failures, and a high short-term mortality rate. The comprehensive medical treatment efficacy of ACLF is currently limited; thus, liver transplantation is the only viable potential treatment method. However, considering the severe liver donor shortage, economic and social costs, as well as the differences in disease severity and prognosis of different disease courses, it is particularly important to accurately assess the benefits of liver transplantation in patients with ACLF. Early identification and prediction, timing, prognosis, and survival benefits are discussed here by combining the latest research findings so as to optimize the liver transplantation treatment strategy for ACLF.
