Research progress of mesenchymal stem cell-derived extracellular vesicles in liver diseases.
10.3760/cma.j.cn501113-20230320-00123
- VernacularTitle:间充质干细胞源性细胞外囊泡在肝脏疾病中的研究进展
- Author:
Liu YANG
1
;
Bai Sui FENG
1
Author Information
1. Department of Gastroenterology, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450000, China.
- Publication Type:Journal Article
- Keywords:
Extracellular vesicles;
Liver disease;
Mesenchymal stem cells;
MicroRNA
- MeSH:
Humans;
Extracellular Vesicles;
MicroRNAs/genetics*;
Liver Neoplasms;
Mesenchymal Stem Cells
- From:
Chinese Journal of Hepatology
2023;31(5):556-560
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) transport and transmit intercellular information and play an essential role in physiological and pathological processes. MSC-EVs, MSC-EVs-microRNA, and genetically modified MSC-EVs are involved in the onset and progression of different liver diseases and play a role in reducing liver cell damage, promoting liver cell regeneration, inhibiting liver fibrosis, regulating liver immunity, alleviating liver oxidative stress, inhibiting liver cancer occurrence, and others. Hence, it will replace MSCs as a research hotspot for cell-free therapy. This article reviews the research progress of MSC-EVs in liver diseases and provides a new basis for cell-free therapy of clinical liver diseases.
