A conceptual framework for dynamics of cccDNA in hepatitis B virus.
10.3760/cma.j.cn501113-20230330-00134
- Author:
Jie Li HU
1
;
Ai Long HUANG
1
Author Information
1. Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing 400016, China.
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis B;
Covalently closed circular DNA;
Hepatitis virus
- MeSH:
Humans;
Hepatitis B virus/genetics*;
Hepatitis B, Chronic/drug therapy*;
Antiviral Agents/therapeutic use*;
Virus Replication;
DNA, Circular/therapeutic use*;
DNA, Viral/genetics*;
Hepatitis B/drug therapy*
- From:
Chinese Journal of Hepatology
2023;31(5):545-550
- CountryChina
- Language:Chinese
-
Abstract:
The resolution of the hepatitis C issue has raised expectations for a chronic hepatitis B cure, driving the industry to expand investment in research and development efforts to strengthen functional cure strategies. These strategies have a wide variety of types, and the published research findings are heterogeneous. The theoretical analysis of these strategies is of great significance for determining prioritized research orientations as well as sensibly allocating research and development resources. However, due to a paucity of necessary conceptual models, current theoretical analysis has not been able to unify various therapeutic strategies into a proper theoretical framework. In view of the fact that the decrease in the quantity of cccDNA is an inevitable core event accompanied by the process of functional cure, this paper intends to analyze several chronic hepatitis B cure strategies using cccDNA dynamics as a framework. Furthermore, there are currently few studies on the dynamics of the cccDNA field, hoping that this article can promote recognition and research in this field.
