Ferroptosis and drug-induced liver injury.
10.3760/cma.j.cn501113-20230403-00140
- Author:
Xiao Bo LI
1
Author Information
1. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
- Publication Type:Journal Article
- Keywords:
Acetaminophen;
Drug-induced liver injury;
Ferroptosis
- MeSH:
Humans;
Biomarkers/metabolism*;
Chemical and Drug Induced Liver Injury;
Ferroptosis;
Iron/metabolism*;
Lipid Peroxidation/physiology*
- From:
Chinese Journal of Hepatology
2023;31(4):345-348
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a type of regulated cell death driven by iron-dependent lipid peroxidation that has received extensive attention in recent years. A growing body of evidence suggests that ferroptosis contributes to the progression of drug-induced liver injury. Therefore, the role and mechanism of ferroptosis in the process of drug-induced liver injury deserve further extensive and in-depth exploration, which will aid in the discovery of novel biomarkers as well as the identification of potential approches of targeting ferroptosis to intervene in drug-induced liver injury.
