Drug-induced bile duct injury: progress and challenges.
10.3760/cma.j.cn501113-20230407-00145
- Author:
Dong Liang LI
1
Author Information
1. Department of Hepatobiliary Disease, 900th Hospital of Joint Logistics Support Force (Fuzhou General Clinical Medical College of Fujian Medical University), Fuzhou 350025, China.
- Publication Type:Journal Article
- Keywords:
Decondary sclerosing cholangitis;
Immune mediated cholangitis;
Progression;
Vanishing bile duct syndrome
- MeSH:
Humans;
Cholestasis/chemically induced*;
Cholangitis, Sclerosing/diagnosis*;
Chemical and Drug Induced Liver Injury/pathology*;
Bile Ducts/pathology*
- From:
Chinese Journal of Hepatology
2023;31(4):339-344
- CountryChina
- Language:Chinese
-
Abstract:
Drug-induced bile duct injury is a specific kind of drug-induced liver injury that has two main pathological types, namely ductopenia, or vanishing bile duct syndrome, and secondary sclerosing cholangitis. However, in recent years, the reports of new drugs that cause bile duct injury have been constantly increasing, and these drugs have different clinicopathological features and a novel pathogenesis. Therefore, this paper summarizes and analyzes the progress and challenges in the etiology, pathogenesis, diagnosis and treatment, and other aspects of drug-induced bile duct injury.
