Oligonucleotide drugs and their progress in stomatology.
10.3760/cma.j.cn112144-20220829-00465
- Author:
Hong ZHAO
1
;
Zhi Min ZHANG
1
;
Xin Ying ZOU
1
;
Fei Long REN
1
;
Shuang GAO
1
Author Information
1. Department of Endodontics, Hospital of Stomatology, Jilin University, Changchun 130021, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Alveolar Bone Loss;
Biofilms;
Bone Regeneration;
Oligonucleotides;
Oral Medicine
- From:
Chinese Journal of Stomatology
2023;58(6):603-608
- CountryChina
- Language:Chinese
-
Abstract:
Oligonucleotide drugs have the characteristics of targeting, modifiability and high biosafety. Recent studies have shown that oligonucleotide can be used to make biosensors, vaccine adjuvants, and has the functions of inhibiting alveolar bone resorption, promoting jaw and alveolar bone regeneration, anti-tumor, destroying plaque biofilm, and precise control of drug release. Therefore, it has a broad application prospect in the field of stomatology. This article reviews the classification, action mechanism and research status of oligonucleotide in stomatology. The aim is to provide ideas for further research and application of oligonucleotide.
