The relationship between hepatitis B virus infection and the incidence of pancreatic cancer: a retrospective case-control study.
10.3350/kjhep.2010.16.1.49
- Author:
Seung Goun HONG
1
;
Ji Hoon KIM
;
Young Sun LEE
;
Eileen YOON
;
Hyun Jung LEE
;
Jin Ki HWANG
;
Eun Suk JUNG
;
Moon Kyung JOO
;
Young Kul JUNG
;
Jong Eun YEON
;
Jong Jae PARK
;
Jae Seon KIM
;
Young Tae BAK
;
Kwan Soo BYUN
Author Information
1. Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. kjhhepar@naver.com
- Publication Type:Original Article ; English Abstract
- Keywords:
Hepatitis B virus;
HBsAg;
Anti-HCV;
Pancreatic cancer
- MeSH:
Aged;
Case-Control Studies;
Data Interpretation, Statistical;
Female;
Hepatitis B/*complications/diagnosis;
Hepatitis C/complications/diagnosis;
Humans;
Incidence;
Male;
Middle Aged;
Odds Ratio;
Pancreatic Neoplasms/diagnosis/*epidemiology/etiology;
Retrospective Studies;
Risk Factors
- From:The Korean Journal of Hepatology
2010;16(1):49-56
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: An association between past history of hepatitis B virus (HBV) infection and pancreatic cancer (PC) has recently been reported. We investigated whether HBV and hepatitis C virus (HCV) infections are associated with the development of PC in Korea. METHODS: We retrospectively recruited patients with PC and sex- and, age-matched control patients with stomach cancer (SC) during the previous 5 years. Serum HBsAg and anti-HCV were examined, and data on smoking, alcohol intake, diabetes, and the history of chronic pancreatitis (CP) were collected. RESULTS: A total of 506 PC and 1008 SC were enrolled, with respectively 58.1% and 97.3% of these cases being confirmed histologically. The mean age and sex ratio (male:female) were 63.5 years and 1.5:1 in the PC patients and 63.9 years and 1.5:1 in the SC patients respectively (P>0.05). The odds ratios (95% confidence interval, 95% CI) in univariate analysis were 0.90 (0.52-1.56; P=0.70) for HBsAg, 1.87 (0.87-4.01; P=0.11) for anti-HCV, 2.66 (2.04-3.48; P<0.001) for the presence of diabetes, 2.30 (1.83-2.90; P<0.001) for smoking, 1.14 (0.89-1.46; P=0.31) for alcohol intake, and 4.40 (1.66-11.66; P=0.003) for the history of CP. Independent risk factors for PC were presence of diabetes (OR, 2.67; 95% CI, 2.00-3.56; P<0.001), smoking (OR, 2.49; 95% CI, 1.93-3.21; P<0.001) and history of CP (OR, 4.60; 95% CI, 1.56-13.53; P=0.006). CONCLUSIONS: There was no significant association between seropositivity for HBsAg or anti-HCV and PC. Further studies are warranted to clarify the association between HBV infection and PC in regions where HBV is endemic.
