A case of hemophagocytic syndrome complicated by acute viral hepatitis A infection.
10.3350/kjhep.2010.16.1.79
- Author:
Ji Young SEO
1
;
Dong Dae SEO
;
Tae Joo JEON
;
Tae Hoon OH
;
Won Chang SHIN
;
Won Choong CHOI
;
Soo Jin YOO
;
Tae Hee HAN
Author Information
1. Department of Internal Medicine, Inje University College of Medicine, Sanggye Paik Hospital, Seoul, Korea. seodd@paik.ac.kr
- Publication Type:Case Report ; English Abstract
- Keywords:
Hepatitis A;
Lymphohistiocytosis;
Hemophagocytic
- MeSH:
Acute Disease;
Disseminated Intravascular Coagulation/complications;
Female;
Hemorrhage/complications;
Hepatitis A/complications/*diagnosis;
Humans;
Liver Failure, Acute/complications;
Lymphohistiocytosis, Hemophagocytic/complications/*diagnosis;
Tomography, X-Ray Computed;
Young Adult
- From:The Korean Journal of Hepatology
2010;16(1):79-82
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hemophagocytic syndrome (HPS) is a rare but serious condition that is histopathologically characterized by activation of macrophage or histiocytes with hemophagocytosis in bone marrow and reticuloendothelial systems. Clinically it presents with high fever, hepatosplenomegaly, pancytopenia, liver dysfunction, and hyperferritinemia. Hepatitis A virus is a very rare cause of secondary HPS. We report a case of a 22-year-old woman infected by hepatitis A virus who was consequently complicated with HPS. She presented typical clinical features of acute hepatitis A, and showed clinical and biochemical improvements. However, HPS developed as a complication of acute hepatitis A and the patient died of intraperitoneal bleeding caused by hepatic decompensation and disseminated intravascular coagulation.
