Clinical characteristics and follow-up analysis of 12 patients of acute phosphine poisoning.
10.3760/cma.j.cn121094-20220809-00395
- VernacularTitle:12例急性磷化氢中毒患者的临床特征及随访分析
- Author:
Qian ZHANG
1
;
Shuang Li YANG
1
;
Shi Wen YU
1
;
Qiao YE
1
Author Information
1. Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
- Publication Type:Journal Article
- Keywords:
Aluminium phosphide;
Phosphines;
Poisoning;
Pulmonary function;
Residual symptoms
- MeSH:
Humans;
Follow-Up Studies;
Phosphines;
Lung;
Lung Diseases;
Aluminum Compounds;
Poisoning/diagnosis*
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2023;41(7):552-554
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the clinical characteristics of patients with acute phosphine poisoning, and to follow up and evaluate the prognosis of patients. Methods: In May 2022, 12 patients with phosphine poisoning by respiratory inhalation in Beijing Chao-Yang Hospital of Capital Medical University were analyzed. The patients were treated with symptomatic support therapy. Three months later, patients were re-evaluated the symptoms of poisoning, pulmonary function and magnetic resonance imaging (MRI) of the brain to understand the prognosis of the phosphine poisoning. Results: The main symptoms of 12 patients were respiratory and central nervous system symptoms with hypoxia. The symptoms of poisoning improved after treatment. Follow-up found that the patients had different degrees of residual symptoms. Pulmonary function showed increased airway resistance. Airway challenge test was positive in some patients. MRI of the head of some patients showed small ischemic focus in bilateral frontal lobes. Conclusion: Acute phosphine poisoning may cause persistent damage to the respiratory system and central system, and residual symptoms after 3 months.
