Progress on the mechanism of n-hexane induced toxic effects in vitro and in vivo.
10.3760/cma.j.cn121094-20220303-00109
- VernacularTitle:正己烷体内外诱导毒性效应的机制研究进展
- Author:
Lian Jing ZHANG
1
;
Wen Ting FENG
2
;
Jian Jun LIU
1
Author Information
1. Guangdong Medical University School of Public Health, Shenzhen 518020, China Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen Health Toxicology Medical Key Discipline (2020-2024), Shenzhen 518020, China.
2. Shenzhen Institute of Occupational Disease Control and Prevention, Occupational Health Care Institute Guangdong, Shenzhen 518020, China.
- Publication Type:Journal Article
- Keywords:
2, 5-hexanedione;
Chronic;
Mechanism study;
Toxic effects;
n-hexane
- MeSH:
Humans;
Hexanes/toxicity*;
Hexanones;
Industry;
Solvents
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2023;41(5):388-396
- CountryChina
- Language:Chinese
-
Abstract:
Hexane is a widely used organic solvent in industry, and chronic hexane poisoning is the main occupational toxic lesion in China. In particular, axonal and myelin lesions in the distal thick fibers of the peripheral nervous system may be caused by 2, 5-hexanedione (2, 5-HD), an intermediate metabolite of n-hexane in humans. Hexane has toxic effects not only on the nervous system but also on the liver, kidneys, and reproductive organs. In this paper, we review the progress of research on the mechanism of n-hexane toxic neuropathy.
