Determination of cobalt and tungsten in human urine by inductively coupled plasma mass spectrometry.
10.3760/cma.j.cn121094-20211214-00614
- VernacularTitle:尿中钴和钨测定的电感耦合等离子体质谱法
- Author:
Liu YANG
1
;
Chao Yang WANG
1
;
Yu Dan ZHANG
1
;
Qi GENG
1
;
Wen Hua QIN
1
Author Information
1. The Third People's Hospital of Henan Province (Henan Hospital for Occupational Diseases) Occupational and Environmental Testing and Inspection Center, Henan Provincial Key Laboratory of Chemical Toxicology Detection, Zhengzhou 450052, China.
- Publication Type:Journal Article
- Keywords:
Cobalt;
Mass Spectrometry;
Tungsten;
Urine;
Workplace
- MeSH:
Humans;
Cobalt/analysis*;
Tungsten/analysis*;
Spectrum Analysis;
Nitric Acid;
Mass Spectrometry
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2023;41(5):371-374
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To establish a inductively coupled plasma mass spectrometry method for the determination of trace cobalt and tungsten in human urine. Methods: The authors used 1% nitric acid solution as diluent in October-December 2021, the sample dilution factor and internal standard element were optimized by single factor rotation experiment, and the difference between the working curve and the standard curve was compared. Results: The method uses working curve to determine cobalt and tungsten in urine, the linear range of this method was 0.0~10.0 μg/L, the correlation coefficient was 0.999 9, the detection limits respectively were 0.005 μg/L (cobalt) and 0.09 μg/L (tungsten), the recoveries of samples respectively were 87.0%~100.2% (cobalt) and 89.4%~104.8% (tungsten), the relative standard deviations respectively were 0.4%~4.4% (cobalt) and 0.6%~3.8% (tungsten) . Conclusion: A simple and rapid method for determination of cobalt and tungsten in urine has been established. This method has the advantages of simple operation, high sensitivity, low detection limit and good stability. It is suitable for determination of cobalt and tungsten in urine of all kinds of people.
