Research Progress on Ferroptosis-mediated Antitumor Immunotherapy
10.3971/j.issn.1000-8578.2023.22.1321
- VernacularTitle:铁死亡介导的抗肿瘤免疫治疗研究进展
- Author:
Guiqin HUANG
1
;
Yu FU
;
Mingxing MIAO
;
Tianhua YAN
Author Information
1. Department of Physiology and Pharmacology, College of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China
- Publication Type:Research Article
- Keywords:
Ferroptosis;
Cancer;
Immunotherapy;
Immune cells
- From:
Cancer Research on Prevention and Treatment
2023;50(7):700-704
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a form of programmed cell death driven by iron-dependent lipid peroxidation and is closely associated with a wide range of biological processes, such as aging, immunity, and cancer. Tumor multidrug resistance, especially resistance to apoptosis, has prompted the urgent search for a new antitumor treatment option. Remarkable progress has been made in the study of the role of ferroptosis in antitumor, especially the interaction with immune cells. Studying immunotherapy based on ferroptosis pathways has become a new direction in antitumor research. In this work, we review the role of ferroptosis in immune cells and antitumor immunotherapy to provide new ideas for ferroptosis-mediated antitumor immunotherapy.
