Progress and reflection of conversion therapy for locally advanced pancreatic cancer.
10.3760/cma.j.cn112139-20230329-00128
- VernacularTitle:局部进展期胰腺癌转化治疗的进展与思考
- Author:
Jin XU
1
,
2
,
3
;
Xian Jun YU
1
,
2
,
3
Author Information
1. Department of Pancreatic Surgery and Comprehensive Treatment,Fudan University Shanghai Cancer Center
2. Shanghai Pancreatic Cancer Institute
3. Pancreatic Cancer Institute, Fudan University,Shanghai 200032,China.
- Publication Type:Journal Article
- MeSH:
Humans;
Prospective Studies;
Pancreatic Neoplasms/drug therapy*;
Neoadjuvant Therapy;
Antineoplastic Combined Chemotherapy Protocols/therapeutic use*
- From:
Chinese Journal of Surgery
2023;61(7):540-545
- CountryChina
- Language:Chinese
-
Abstract:
With the improvement of nonsurgical treatment in pancreatic cancer, the increasing accuracy of subclassification of anatomy, and the continuous refinement of surgical resection techniques, more and more locally advanced pancreatic cancer(LAPC) patients have the opportunity to undergo conversion surgery and achieve survival benefits,which has attracted the attention of scholars in this field. Despite the numerous prospective clinical studies conducted, there is still a lack of high-level evidence-based medical evidence in terms of conversion treatment strategies, efficacy evaluation, surgical timing and survival prognosis, and there are not yet specific quantitative standards and guiding principles for conversion treatment for these patients in clinical practice, and the indications for surgical resection rely more on the experience of each center or surgeon, lacking consistency. Therefore,the indicators for the evaluation of the efficacy of conversion treatment in patients with LAPC were summarized to reflect on the different modes of conversion treatment and clinical outcomes currently being explored, expecting to provide more accurate recommendations and guidance for the clinic.
