Pathological features of early gastric cancer and its background mucosa after eradication of Helicobacter pylori and their implications for biopsy diagnosis.
10.3760/cma.j.cn112151-20220725-00649
- VernacularTitle:根除幽门螺杆菌后早期胃癌和背景黏膜病理学特征及其对活检病理诊断的提示意义
- Author:
Xiao Yu SUN
1
;
Jing LI
2
;
Bing YUE
3
;
Rui XU
3
;
Mei JIA
3
;
Yang GAO
3
;
Guang Yong CHEN
3
Author Information
1. Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China Department of Pathology, Zibo Central Hospital, Zibo 255036, China.
2. Department of Pathology, Zibo Central Hospital, Zibo 255036, China.
3. Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Helicobacter pylori;
Helicobacter Infections/drug therapy*;
Stomach Neoplasms/pathology*;
Gastric Mucosa/pathology*;
Biopsy
- From:
Chinese Journal of Pathology
2023;52(5):460-465
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the clinicopathological changes of early gastric cancer, especially its background mucosa, after the eradication of Helicobacter pylori (H. pylori), and to investigate the causes of underdiagnosis in preoperative biopsy pathology. Methods: Ninety cases of early gastric cancer after H. pylori eradication and 120 cases of endoscopic submucosal dissection (ESD) specimens without H. pylori eradication and their corresponding biopsy specimens were collected from Beijing Friendship Hospital Affiliated to Capital Medical University during 2016-2021. The clinicopathological data of the patients were analyzed, and the histopathological characteristics and immunophenotypic results compared. Results: Compared with the early gastric cancer without H. pylori eradication history, the histopathological type of early gastric cancer after H. pylori eradication was differentiated adenocarcinoma, with staggered distribution of cancerous and non-cancerous epithelium in the tumor area. The morphologic characteristics of gastric mucosa in the background of early gastric cancer after H. pylori eradication, were distinctive, including widening of the opening of enterosylated glandular ducts, serrated change of luminal margin, eosinophilic and microvesicular cytoplasm of enterosylated epithelium. Low-grade atypia existed in gastric cancer epithelial cells after sterilization, which might lead to underdiagnosis or missed diagnosis in biopsy pathology. Conclusions: Early gastric cancer and its background mucosa after H. pylori eradication have unique morphological characteristics, which can be used as a clue for pathological diagnosis, improve the accuracy of biopsy pathology and reduce the underdiagnosis.
