Clinicopathological characteristics of Klinefelter syndrome: a testicular biopsy analysis of 87 cases.
10.3760/cma.j.cn112151-20221216-01045
- Author:
Shu Yan TIAN
1
;
Yan LI
1
;
Lian Ming ZHAO
2
;
Hui Ying HE
1
Author Information
1. Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Beijing 100191, China.
2. Department of Urology, Peking University Third Hospital,Beijing 100191, China.
- Publication Type:Journal Article
- MeSH:
Male;
Humans;
Testis/pathology*;
Klinefelter Syndrome/pathology*;
Retrospective Studies;
Seminiferous Tubules/pathology*;
Biopsy
- From:
Chinese Journal of Pathology
2023;52(4):341-346
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the clinicopathological characteristics of testicular biopsies from Klinefelter syndrome (KS) patients. Methods: The testicular biopsy specimens of 87 patients with KS (a total of 107 biopsy specimens) were collected from the Department of Pathology, Peking University Third Hospital, Beijing, China from January 2017 to July 2022. All patients were diagnosed as KS by peripheral blood karyotyping analysis. The testicular histopathologic features, testicular volume and hormone levels were evaluated retrospectively. The histopathologic analysis was used to assess the quantity and morphology of Leydig cells, the spermatogenic state of seminiferous tubules, the thickening of the basement membrane of seminiferous tubules and the changes of stroma. Results: Leydig cell proliferative nodules were seen in 95.3% (102/107) of KS testicular biopsy tissues. The eosinophilic inclusion bodies and lipofuscin in Leydig cells were found in 52.3% (56/107) and 57.9% (62/107) of specimens, respectively. The Sertoli cell only seminiferous tubules and the hyalinized tubules were found in 66.4% (71/107) and 76.6% (82/107) of the examined tissues, respectively. The tubules with complete spermatogenic arrest were found in 15.9% (17/107) of specimens, and 5.6% (6/107) of the specimens showed low spermatogenesis or incomplete spermatogenic arrest. In 85.0% (91/107) of the specimens, increased thick-walled small vessels with hyaline degeneration were identified. Conclusions: The most common features of KS testicular specimens are Leydig cell proliferative nodules, hyaline degeneration of seminiferous tubules and proliferation of thick-walled blood vessels. Testicular biopsy specimens of KS are rare. The pathologists can make a tentative diagnosis of KS based on the histological findings, combined with the ultrasound and laboratory results, which is helpful for further diagnosis and treatment of KS.
