Epidemiological distribution characteristics of peripheral blood mosaic chromosomal alteration in adults from 10 regions of China.
10.3760/cma.j.cn112338-20230306-00129
- Author:
Ming Yu SONG
1
;
Yu Xuan ZHAO
1
;
Yu Ting HAN
1
;
Jun LYU
2
;
Can Qing YU
2
;
Pei PEI
3
;
Huai Dong DU
4
;
Jun Shi CHEN
5
;
Zheng Ming CHEN
6
;
Dian Jian Yi SUN
2
;
Li Ming LI
2
Author Information
1. Key Laboratory of Epidemiology of Major Diseases, Ministry of Education/Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
2. Key Laboratory of Epidemiology of Major Diseases, Ministry of Education/Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China.
3. Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China.
4. Medical Research Council Population Health Research Unit, University of Oxford, Oxford OX3 7LF, United Kingdom Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, United Kingdom.
5. China National Center for Food Safety Risk Assessment, Beijing 100022, China.
6. Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, United Kingdom.
- Publication Type:Journal Article
- MeSH:
Adult;
Female;
Humans;
Male;
Middle Aged;
China/epidemiology*;
Life Style;
Risk Factors;
Smoking/epidemiology*;
Aged
- From:
Chinese Journal of Epidemiology
2023;44(7):1021-1026
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To describe the epidemiological distribution characteristics of peripheral blood mosaic chromosomal alteration (mCA) in community adults aged 30-79 years in 10 regions of China. Methods: A total of 100 297 participants with complete baseline information (demographic characteristics, lifestyle, physical examination, etc.) and genotyping data of blood-derived DNA in ten regions of the China Kadoorie Biobank study were included. The mCAs were detected with the Mosaic Chromosomal Alterations pipeline, and logistic regression models were used to compare the differences in the detection rate of mCAs in different regions and populations. Results: A total of 5 810 mCA carriers were detected, with the detection rate of 5.8%. The standardized detection rate was 5.1%. The baseline detection rate of mCA increased with age, which were 3.4%, 5.0%, and 9.4% in those aged 30-, 51-, and >60 years, respectively (trend test P<0.001). A more significant proportion of mCAs were found in men (8.0%) than women (4.0%), as well as in urban areas (6.4%) than in rural areas (5.3%), the difference was significant (P<0.001). After adjusting for age and gender, the detection rate of mCA was higher in current smokers or people quitting smoking due to illness and people with low physical activity level, and the mCA detection rate was lower in obesy people (5.3%) than that in people with normal body weight (5.9%) (P=0.006). Conclusions: The detection rate of mCAs varied with region and population in community adults aged 30-79 years in 10 regions of China. The study results might contribute to the molecular identification of aging populations and guide precision prevention of age-related diseases such as cancers.
