Causal links between long-term exposure to NO2 and the risk of cardiovascular hospitalization.
10.3760/cma.j.cn112338-20221122-00989
- Author:
Yu Qin ZHANG
1
;
Ao LUO
2
;
Shi Rui CHEN
1
;
Xu JU
1
;
Xiu Yuan CHEN
3
;
Wang Jian ZHANG
1
;
Yuan Tao HAO
4
Author Information
1. Department of Medical Statistics, School of Public Health/Sun Yat-sen Global Health Institute/Center for Health Information Research, Sun Yat-sen University, Guangzhou 510080, China.
2. Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
3. The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China.
4. Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Adult;
Middle Aged;
Aged;
Nitrogen Dioxide;
Prospective Studies;
Cardiovascular Diseases/epidemiology*;
Causality;
Hospitalization
- From:
Chinese Journal of Epidemiology
2023;44(6):885-890
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine the causal association between long-term Nitrogen dioxide (NO2) exposure and the risk of cardiovascular hospitalization. Methods: Based on a sub-cohort of a community-based prospective cohort study, a total of 36 271 participants were recruited from 35 communities randomly selected in Guangzhou in 2015. The annual average exposure of NO2, demographic characteristics, lifestyle factors, and information on the causes of hospitalization was collected. We applied marginal structural Cox models to investigate the effect of NO2 on cardiovascular hospitalization. Demographic and behavioral factors also stratified results. Results: The mean age of participants in the present study was (50.9±17.8) years, and the cardiovascular admission rate was 8.7%, with 203 822 person-years of follow-up. The annual mean NO2 concentration was 48.7 μg/m3 during 2015-2020. For each 10 μg/m3 increase in NO2 concentrations, the HRs (95%CIs) of total cardiovascular hospitalization, cardiovascular hospitalization, and cerebrovascular hospitalization were 1.33 (1.16-1.52), 1.36 (1.16-1.60) and 1.25 (1.00-1.55), respectively. Participants who were never married/married, with secondary education, high exercise frequency, or non-smokers/current smokers may be more susceptible than their counterparts. Conclusion: Long-term exposure to NO2 significantly increased hospitalization risk for cardiovascular disease.
