Incidence of chronic obstructive pulmonary disease and risk factors in the Suzhou cohort.
10.3760/cma.j.cn112338-20221202-01033
- Author:
Meng Shi YANG
1
;
Xi Kang FAN
2
;
Jian SU
2
;
Hao YU
2
;
Yan LU
3
;
Yu Jie HUA
3
;
Pei PEI
4
;
Jun LYU
5
;
Ran TAO
2
;
Jin Yi ZHOU
2
;
Ming WU
6
Author Information
1. Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing 210009, China.
2. Department of Non-communicable Chronic Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
3. Department of Non-communicable Chronic Disease Control and Prevention, Suzhou Center for Disease Control and Prevention, Suzhou 215004, China.
4. Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China.
5. Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing 100191, China Department of Epidemiology and Health Statistics, School of Public Health, Peking University, Beijing 100191, China.
6. Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing 210009, China Department of Non-communicable Chronic Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Incidence;
Pulmonary Disease, Chronic Obstructive/epidemiology*;
Risk Factors;
Smoking/epidemiology*;
Tobacco Smoking
- From:
Chinese Journal of Epidemiology
2023;44(6):868-876
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To understand the incidence of chronic obstructive pulmonary disease (COPD) in the Suzhou cohort, and explore the risk factors for the development of COPD in Suzhou, and provide a scientific basis for COPD prevention. Methods: This study was based on the China Kadoorie Biobank project in Wuzhong District, Suzhou. After excluding individuals with airflow obstruction and self-reported chronic bronchitis, emphysema, or pulmonary heart disease at baseline, 45 484 individuals were finally included in the analysis. Cox proportional risk models were used to analyze risk factors of COPD and calculate hazard ratios and 95% confidence interval (CI) in the Suzhou cohort. The effect modifications of smoking on the association between other risk factors and COPD were evaluated. Results: Complete follow-up was available through December 31, 2017. Participants were followed up for a median of 11.12 years, and 524 individuals were diagnosed with COPD during the follow-up period; the incidence was 105.54 per 100 000 person-years. Multivariate Cox proportional risk regression models showed that age (HR=3.78, 95%CI:3.32-4.30), former smoking (HR=2.00, 95%CI:1.24-3.22), current smoking (<10 cigarettes/day, HR=2.14, 95%CI:1.36-3.35;≥10 cigarettes/day, HR=2.69, 95%CI:1.60-4.54), history of respiratory disease (HR=2.08, 95%CI:1.33-3.26), daily sleep duration ≥10 hours (HR=1.41, 95%CI:1.02-1.95) were associated with increased risk of COPD. However, education level of primary school and above (primary or junior high school, HR=0.65, 95%CI:0.52-0.81; high school and above, HR=0.54, 95%CI:0.33-0.87), consuming fresh fruit daily (HR=0.59, 95%CI:0.42-0.83) and consuming spicy food weekly (HR=0.71, 95%CI:0.53-0.94) were associated with reduced risk of COPD. Conclusions: The incidence of COPD is low in Suzhou. Older age, smoking, history of respiratory disease, and long sleep duration were risk factors for the development of COPD in the Suzhou cohort.
