Scoping review of progress in cohort studies of autism spectrum disorder.
10.3760/cma.j.cn112338-20221027-00918
- Author:
Yun Xiao WU
1
;
Zhi Xia LI
2
;
Xiao Zhen LYU
3
;
Mai WANG
4
;
Tian Yu HUANG
1
;
Jian Hong CHENG
5
;
Ruo gu MENG
4
Author Information
1. School of Public Health, Peking University, Beijing 100191, China.
2. Education Department, Peking University Health Science Center, Beijing 100191, China.
3. The Sixth Hospital of Peking University, Beijing 100191, China.
4. National Institute of Health Data Science, Peking University, Beijing 100191, China.
5. Beijing ALSOABA Technology Company Limited, Beijing 102200, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Autism Spectrum Disorder;
Cohort Studies;
Databases, Factual
- From:
Chinese Journal of Epidemiology
2023;44(5):837-844
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To understand the status of autism spectrum disorder (ASD) cohort studies and explore the feasibility of constructing ASD disease-specific cohorts based on real-world data (RWD). Methods: ASD cohort studies published by December 2022 were collected by literature retrieval from major Chinese and English databases. And the characteristics of the cohort were summarized. Results: A total of 1 702 ASD cohort studies were included, and only 60 (3.53%) were from China. A total of 163 ASD-related cohorts were screened, of which 55.83% were birth cohorts, 28.22% were ASD-specific cohorts, and 4.91% were ASD high-risk cohorts. Most cohorts used RWD such as hospital registries or conducted community-based field surveys to obtain participant information and identified patients with ASD by scales or clinical diagnoses. The contents of the studies included ASD incidence and prognostic risk factors, ASD comorbidity patterns and the impact of ASD on self-health and their offspring's health. Conclusions: ASD cohort studies in developed countries have been in the advanced stage, while the Chinese studies are still in their infancy. RWD provides the data basis for ASD-specific cohort construction and offers new opportunities for research, but work such as case validation is still needed to ensure the scientific nature of cohort construction.
