Association between gestational diabetes mellitus and preterm birth subtypes.
10.3760/cma.j.cn112338-20220927-00815
- Author:
Kai Lin WANG
1
;
Miao ZHANG
1
;
Qing LI
2
;
Hui KAN
1
;
Hai Yan LIU
3
;
Yu Tong MU
1
;
Zong Guang LI
3
;
Yan Min CAO
1
;
Yao DONG
1
;
An Qun HU
3
;
Ying Jie ZHENG
1
Author Information
1. Department of Epidemiology, Key Laboratory of Public Health Safety of Ministry of Education, Key Laboratory for Health Technology Assessment, National Commission of Health/School of Public Health, Fudan University, Shanghai 200032, China.
2. Department of Obstetrics and Gynecology, Anqing Prefectural Hospital, Anhui Province, Anqing 246003, China.
3. Department of Clinical Laboratory, Anqing Prefectural Hospital, Anhui Province, Anqing 246003, China.
- Publication Type:Journal Article
- MeSH:
Infant, Newborn;
Female;
Pregnancy;
Humans;
Premature Birth;
Diabetes, Gestational;
Obstetric Labor, Premature;
Hospitals;
Iatrogenic Disease
- From:
Chinese Journal of Epidemiology
2023;44(5):809-815
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the association between gestational diabetes mellitus (GDM) and preterm birth subtypes. Methods: Based on the cohort of pregnant women in Anqing Prefectural Hospital, the pregnant women who received prenatal screening in the first or second trimesters were recruited into baseline cohorts; and followed up for them was conducted until delivery, and the information about their pregnancy status and outcomes were obtained through electronic medical record system and questionnaire surveys. The log-binomial regression model was used to explore the association between GDM and preterm birth [iatrogenic preterm birth, spontaneous preterm birth (preterm premature rupture of membranes and preterm labor)]. For multiple confounding factors, the propensity score correction model was used to compute the adjusted association. Results: Among the 2 031 pregnant women with a singleton delivery, the incidence of GDM and preterm birth were 10.0% (204 cases) and 4.4% (90 cases) respectively. The proportions of iatrogenic preterm birth and spontaneous preterm birth in the GDM group (n=204) were 1.5% and 5.9% respectively, while the proportions in non-GDM group (n=1 827) were 0.9% and 3.2% respectively, and the difference in the proportion of spontaneous preterm birth between the two groups was significant (P=0.048). Subtypes of spontaneous preterm were further analyzed, and the results showed that the proportions of preterm premature rupture of membranes and preterm labor in the GDM group were 4.9% and 1.0% respectively, while the proportions in the non-GDM group were 2.1% and 1.1% respectively. It showed that the risk of preterm premature rupture of membranes in GDM pregnant women was 2.34 times (aRR=2.34, 95%CI: 1.16-4.69) higher than that in non-GDM pregnant women. Conclusions: Our results showed that GDM might increase the risk of preterm premature rupture of membranes. No significant increase in the proportion of preterm labor in pregnant women with GDM was found.
