A descriptive analysis of hyperlipidemia in adult twins in China.
10.3760/cma.j.cn112338-20221007-00859
- Author:
Ke MIAO
1
;
Wei Hua CAO
1
;
Jun LYU
1
;
Can Qing YU
1
;
Sheng Feng WANG
1
;
Tao HUANG
1
;
Dian Jian Yi SUN
1
;
Chun Xiao LIAO
1
;
Yuan Jie PANG
1
;
Zeng Chang PANG
2
;
Min YU
3
;
Hua WANG
4
;
Xian Ping WU
5
;
Zhong DONG
6
;
Fan WU
7
;
Guo Hong JIANG
8
;
Xiao Jie WANG
9
;
Yu LIU
10
;
Jian DENG
11
;
Lin LU
12
;
Wen Jing GAO
1
;
Li Ming LI
1
Author Information
1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
2. Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China.
3. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
4. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
5. Sichuan Center for Disease Control and Prevention, Chengdu 610041, China.
6. Beijing Center for Disease Prevention and Control , Beijing 100013, China.
7. Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
8. Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
9. Qinghai Center for Disease Prevention and Control , Xining 810007, China.
10. Heilongjiang Provincial Center for Disease Control and Prevention, Harbin 150090, China.
11. Handan Center for Disease Control and Prevention of Hebei Province, Handan 056001, China.
12. Yunnan Center for Disease Control and Prevention, Kunming 650034, China.
- Publication Type:Twin Study
- MeSH:
Adult;
Female;
Humans;
Male;
Middle Aged;
Young Adult;
China/epidemiology*;
Diseases in Twins/genetics*;
Hyperlipidemias/genetics*;
Metabolic Diseases;
Twins, Dizygotic;
Twins, Monozygotic/genetics*
- From:
Chinese Journal of Epidemiology
2023;44(4):544-551
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To describe the distribution characteristics of hyperlipidemia in adult twins in the Chinese National Twin Registry (CNTR) and explore the effect of genetic and environmental factors on hyperlipidemia. Methods: Twins recruited from the CNTR in 11 project areas across China were included in the study. A total of 69 130 (34 565 pairs) of adult twins with complete information on hyperlipidemia were selected for analysis. The random effect model was used to characterize the population and regional distribution of hyperlipidemia among twins. The concordance rates of hyperlipidemia were calculated in monozygotic twins (MZ) and dizygotic twins (DZ), respectively, to estimate the heritability. Results: The age of all participants was (34.2±12.4) years. This study's prevalence of hyperlipidemia was 1.3% (895/69 130). Twin pairs who were men, older, living in urban areas, married,had junior college degree or above, overweight, obese, insufficient physical activity, current smokers, ex-smokers, current drinkers, and ex-drinkers had a higher prevalence of hyperlipidemia (P<0.05). In within-pair analysis, the concordance rate of hyperlipidemia was 29.1% (118/405) in MZ and 18.1% (57/315) in DZ, and the difference was statistically significant (P<0.05). Stratified by gender, age, and region, the concordance rate of hyperlipidemia in MZ was still higher than that in DZ. Further, in within-same-sex twin pair analyses, the heritability of hyperlipidemia was 13.04% (95%CI: 2.61%-23.47%) in the northern group and 18.59% (95%CI: 4.43%-32.74%) in the female group, respectively. Conclusions: Adult twins were included in this study and were found to have a lower prevalence of hyperlipidemia than in the general population study, with population and regional differences. Genetic factors influence hyperlipidemia, but the genetic effect may vary with gender and area.
