A descriptive analysis on hypertension in adult twins in China.
10.3760/cma.j.cn112338-20221007-00860
- Author:
Yu Tong WANG
1
;
Wei Hua CAO
1
;
Jun LYU
1
;
Can Qing YU
1
;
Sheng Feng WANG
1
;
Tao HUANG
1
;
Dian Jian Yi SUN
1
;
Chun Xiao LIAO
1
;
Yuan Jie PANG
1
;
Zeng Chang PANG
2
;
Min YU
3
;
Hua WANG
4
;
Xian Ping WU
5
;
Zhong DONG
6
;
Fan WU
7
;
Guo Hong JIANG
8
;
Xiao Jie WANG
9
;
Yu LIU
10
;
Jian DENG
11
;
Lin LU
12
;
Wen Jing GAO
1
;
Li Ming LI
1
Author Information
1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
2. Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China.
3. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
4. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
5. Sichuan Center for Disease Control and Prevention, Chengdu 610041, China.
6. Beijing Center for Disease Prevention and Control, Beijing 100013, China.
7. Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336,China.
8. Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
9. Qinghai Center for Disease Prevention and Control, Xining 810007, China.
10. Heilongjiang Provincial Center for Disease Control and Prevention, Harbin 150090, China.
11. Handan Center for Disease Control and Prevention of Hebei Province, Handan 056001, China.
12. Yunnan Center for Disease Control and Prevention, Kunming 650034, China.
- Publication Type:Twin Study
- MeSH:
Adult;
Female;
Humans;
Male;
Alcohol Drinking;
Diseases in Twins/genetics*;
Hypertension/genetics*;
Twins, Dizygotic/genetics*;
Twins, Monozygotic/genetics*
- From:
Chinese Journal of Epidemiology
2023;44(4):536-543
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To describe the distribution characteristics of hypertension among adult twins in the Chinese National Twin Registry (CNTR) and to provide clues for exploring the role of genetic and environmental factors on hypertension. Methods: A total of 69 220 (34 610 pairs) of twins aged 18 and above with hypertension information were selected from CNTR registered from 2010 to 2018. Random effect models were used to describe the population and regional distribution of hypertension in twins. To estimate the heritability, the concordance rates of hypertension were calculated and compared between monozygotic twins (MZ) and dizygotic twins (DZ). Results: The age of all participants was (34.1±12.4) years. The overall self-reported prevalence of hypertension was 3.8%(2 610/69 220). Twin pairs who were older, living in urban areas, married, overweight or obese, current smokers or ex-smokers, and current drinkers or abstainers had a higher self-reported prevalence of hypertension (P<0.05). Analysis within the same-sex twin pairs found that the concordance rate of hypertension was 43.2% in MZ and 27.0% in DZ, and the difference was statistically significant (P<0.001). The heritability of hypertension was 22.1% (95%CI: 16.3%- 28.0%). Stratified by gender, age, and region, the concordance rate of hypertension in MZ was still higher than that in DZ. The heritability of hypertension was higher in female participants. Conclusions: There were differences in the distribution of hypertension among twins with different demographic and regional characteristics. It is indicated that genetic factors play a crucial role in hypertension in different genders, ages, and regions, while the magnitude of genetic effects may vary.
