Effect of the varicella vaccination on the clinical characteristics of herpes zoster cases aged 20 years and under.
10.3760/cma.j.cn112150-20220905-00868
- Author:
Mei Ying YOU
1
;
Wei JIANG
2
;
Yue Hua HU
1
;
Miao Miao WANG
1
;
Tian Qi WANG
3
;
Xu Dong LI
1
;
Yi YAN
2
;
Da Peng YIN
4
Author Information
1. Office of Epidemiology, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
2. Institute of Immunization Program, Yichang Center for Disease Control and Prevention, Yichang 443000, China.
3. Office of Epidemiology, Chinese Center for Disease Control and Prevention, Beijing 102206, China Data Resources and Statistics Department, Beijing Municipal Health Big Data and Policy Research Center, Beijing 100034, China.
4. Hainan Center for Disease Control and Prevention, Haikou 570203, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Child;
Female;
Humans;
Male;
Young Adult;
Chickenpox/prevention & control*;
Herpes Zoster/prevention & control*;
Herpes Zoster Vaccine/therapeutic use*;
Herpesvirus 3, Human;
Neuralgia, Postherpetic/prevention & control*
- From:
Chinese Journal of Preventive Medicine
2023;57(7):1059-1062
- CountryChina
- Language:Chinese
-
Abstract:
To discuss the effect of varicella vaccination on the clinical characteristics of herpes zoster (shingles) cases aged 20 years and under, and analyze its clinical features. Based on the Yichang Health Big Data Platform, a descriptive study was conducted to collect the information of cases aged 20 years and under in three medical institutions of Yichang Central People's Hospital, Yichang First People's Hospital and Yichang Second People's Hospital from March 2019 to September 2020. According to the history of varicella vaccine, cases were divided into vaccination group and non-vaccination group, and their clinical features and outcomes were compared. The results showed that 46 shingles cases, aged from 7 to 20 years old, were included in this study. 26 males (56.5%), 20 females (43.5%), 15 cases in vaccination group (32.6%) and 31 cases in non-vaccination group (67.4%). 28 cases had thoracic involvement, followed by lumbar (n=8), cranial (n=7) involvements and extremities (n=7). The spread of herpes skin area: 2 cases involved too large area, 21 cases of 10 cm×10 cm, 14 cases of 5 cm×5 cm, 9 cases of 1 cm×1 cm. Herpes number: 26 cases had 10-49 herpes, followed by <10 herpes (n=9), uncountable herpes (n=7) and 50-99 herpes (n=4). The clinical course[M(Q1,Q3)] lasted 20.5 (13.5,24.8) d averagely, 5 cases had postherpetic neuralgia (PHN) and 1 case had respiratory complications. Shingles decrustation time was significantly shorter in vaccination group (Z=-2.01, P<0.05), and there was no significant difference in other characteristics by vaccination. In conclusion, the number and spread of shingles in most children and adolescents are less, and the complications such as PHN are less. Varicella vaccination can reduce the decrustation time and relieve shingles cases with some clinical symptoms.
