Research progress on mosaic embryo transfer and pregnancy risk.
10.3760/cma.j.cn112150-20221014-00996
- VernacularTitle:嵌合体胚胎移植和妊娠风险的研究进展
- Author:
Yu Wei SONG
1
;
Min JIN
2
Author Information
1. The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China Zhejiang University School of Medicine, Hangzhou 310058, China.
2. The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
- Publication Type:Journal Article
- MeSH:
Pregnancy;
Female;
Infant, Newborn;
Humans;
Preimplantation Diagnosis;
Embryo Transfer;
Pregnancy Outcome;
Genetic Testing;
Embryo Implantation/genetics*
- From:
Chinese Journal of Preventive Medicine
2023;57(6):949-954
- CountryChina
- Language:Chinese
-
Abstract:
Mosaic embryos contain two or more genetically distinct cell lines, which can be detected by pre-implantation genetic testing for aneuploidy. At present, it has been reported that mosaic embryo transfer can lead to healthy live births. In order to prevent severe adverse pregnancy outcomes, such as implantation failure, abortion, congenital malformation and neonatal death after implantation of mosaic embryos, it is critical to carry out genetic counseling, prenatal diagnosis and pregnancy supervision for mosaic embryo transfer. This article reviews the selection of mosaic embryos, the pregnancy outcomes of mosaic embryo transfer, and the safety of offspring, in order to provide references for the clinical practice of mosaic embryo transfer.
